Unexplored Arsenals of Legume Peptides With Potential for Their Applications in Medicine and Agriculture.
Identifieur interne : 000009 ( Main/Exploration ); précédent : 000008; suivant : 000010Unexplored Arsenals of Legume Peptides With Potential for Their Applications in Medicine and Agriculture.
Auteurs : Rui M. Lima [Hongrie] ; Salome Kylarová [Hongrie] ; Peter Mergaert [France] ; Éva Kondorosi [Hongrie]Source :
- Frontiers in microbiology [ 1664-302X ] ; 2020.
Abstract
During endosymbiosis, bacteria live intracellularly in the symbiotic organ of their host. The host controls the proliferation of endosymbionts and prevents their spread to other tissues and organs. In Rhizobium-legume symbiosis the major host effectors are secreted nodule-specific cysteine-rich (NCR) peptides, produced exclusively in the symbiotic cells. NCRs have evolved in the Inverted Repeat Lacking Clade (IRLC) of the Leguminosae family. They are secreted peptides that mediate terminal differentiation of the endosymbionts, forming polyploid, non-cultivable cells with increased membrane permeability. NCRs form an extremely large family of peptides, which have four or six conserved cysteines but otherwise highly diverse amino acid sequences, resulting in a wide variety of anionic, neutral and cationic peptides. In vitro, many synthetic NCRs have strong antimicrobial activities against both Gram-negative and Gram-positive bacteria, including the ESKAPE strains and pathogenic fungi. The spectra and minimal bactericidal and anti-fungal concentrations of NCRs differ, indicating that, in addition to their charge, the amino acid composition and sequence also play important roles in their antimicrobial activity. NCRs attack the bacteria and fungi at the cell envelope and membrane as well as intracellularly, forming interactions with multiple essential cellular machineries. NCR-like peptides with similar symbiotic functions as the NCRs also exist in other branches of the Leguminosae family. Thus, legumes provide countless and so far unexplored sources of symbiotic peptides representing an enormous resource of pharmacologically interesting molecules.
DOI: 10.3389/fmicb.2020.01307
PubMed: 32625188
PubMed Central: PMC7314904
Affiliations:
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Lima</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Plant Biology, Biological Research Centre, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute of Plant Biology, Biological Research Centre, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Kylarova, Salome" sort="Kylarova, Salome" uniqKey="Kylarova S" first="Salome" last="Kylarová">Salome Kylarová</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Plant Biology, Biological Research Centre, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute of Plant Biology, Biological Research Centre, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Mergaert, Peter" sort="Mergaert, Peter" uniqKey="Mergaert P" first="Peter" last="Mergaert">Peter Mergaert</name><affiliation wicri:level="3"><nlm:affiliation>Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author><author><name sortKey="Kondorosi, Eva" sort="Kondorosi, Eva" uniqKey="Kondorosi E" first="Éva" last="Kondorosi">Éva Kondorosi</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Plant Biology, Biological Research Centre, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Institute of Plant Biology, Biological Research Centre, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in microbiology</title><idno type="ISSN">1664-302X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During endosymbiosis, bacteria live intracellularly in the symbiotic organ of their host. The host controls the proliferation of endosymbionts and prevents their spread to other tissues and organs. In Rhizobium-legume symbiosis the major host effectors are secreted nodule-specific cysteine-rich (NCR) peptides, produced exclusively in the symbiotic cells. NCRs have evolved in the Inverted Repeat Lacking Clade (IRLC) of the <i>Leguminosae</i> family. They are secreted peptides that mediate terminal differentiation of the endosymbionts, forming polyploid, non-cultivable cells with increased membrane permeability. NCRs form an extremely large family of peptides, which have four or six conserved cysteines but otherwise highly diverse amino acid sequences, resulting in a wide variety of anionic, neutral and cationic peptides. <i>In vitro</i>, many synthetic NCRs have strong antimicrobial activities against both Gram-negative and Gram-positive bacteria, including the ESKAPE strains and pathogenic fungi. The spectra and minimal bactericidal and anti-fungal concentrations of NCRs differ, indicating that, in addition to their charge, the amino acid composition and sequence also play important roles in their antimicrobial activity. NCRs attack the bacteria and fungi at the cell envelope and membrane as well as intracellularly, forming interactions with multiple essential cellular machineries. NCR-like peptides with similar symbiotic functions as the NCRs also exist in other branches of the <i>Leguminosae</i> family. Thus, legumes provide countless and so far unexplored sources of symbiotic peptides representing an enormous resource of pharmacologically interesting molecules.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32625188</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1664-302X</ISSN><JournalIssue CitedMedium="Print"><Volume>11</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Frontiers in microbiology</Title><ISOAbbreviation>Front Microbiol</ISOAbbreviation></Journal><ArticleTitle>Unexplored Arsenals of Legume Peptides With Potential for Their Applications in Medicine and Agriculture.</ArticleTitle><Pagination><MedlinePgn>1307</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fmicb.2020.01307</ELocationID><Abstract><AbstractText>During endosymbiosis, bacteria live intracellularly in the symbiotic organ of their host. The host controls the proliferation of endosymbionts and prevents their spread to other tissues and organs. In Rhizobium-legume symbiosis the major host effectors are secreted nodule-specific cysteine-rich (NCR) peptides, produced exclusively in the symbiotic cells. NCRs have evolved in the Inverted Repeat Lacking Clade (IRLC) of the <i>Leguminosae</i> family. They are secreted peptides that mediate terminal differentiation of the endosymbionts, forming polyploid, non-cultivable cells with increased membrane permeability. NCRs form an extremely large family of peptides, which have four or six conserved cysteines but otherwise highly diverse amino acid sequences, resulting in a wide variety of anionic, neutral and cationic peptides. <i>In vitro</i>, many synthetic NCRs have strong antimicrobial activities against both Gram-negative and Gram-positive bacteria, including the ESKAPE strains and pathogenic fungi. The spectra and minimal bactericidal and anti-fungal concentrations of NCRs differ, indicating that, in addition to their charge, the amino acid composition and sequence also play important roles in their antimicrobial activity. NCRs attack the bacteria and fungi at the cell envelope and membrane as well as intracellularly, forming interactions with multiple essential cellular machineries. NCR-like peptides with similar symbiotic functions as the NCRs also exist in other branches of the <i>Leguminosae</i> family. Thus, legumes provide countless and so far unexplored sources of symbiotic peptides representing an enormous resource of pharmacologically interesting molecules.</AbstractText><CopyrightInformation>Copyright © 2020 Lima, Kylarová, Mergaert and Kondorosi.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lima</LastName><ForeName>Rui M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Institute of Plant Biology, Biological Research Centre, Szeged, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kylarová</LastName><ForeName>Salome</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Plant Biology, Biological Research Centre, Szeged, Hungary.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mergaert</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kondorosi</LastName><ForeName>Éva</ForeName><Initials>É</Initials><AffiliationInfo><Affiliation>Institute of Plant Biology, Biological Research Centre, Szeged, Hungary.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Microbiol</MedlineTA><NlmUniqueID>101548977</NlmUniqueID><ISSNLinking>1664-302X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ESKAPE bacteria</Keyword><Keyword MajorTopicYN="N">Medicago truncatula</Keyword><Keyword MajorTopicYN="N">antibacterial activity</Keyword><Keyword MajorTopicYN="N">antifungal activity</Keyword><Keyword MajorTopicYN="N">antimicrobial peptide (AMP)</Keyword><Keyword MajorTopicYN="N">multifunctional roles</Keyword><Keyword MajorTopicYN="N">nodule-specific cysteine-rich peptide (NCR)</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>05</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId 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Lima</name></noRegion><name sortKey="Kondorosi, Eva" sort="Kondorosi, Eva" uniqKey="Kondorosi E" first="Éva" last="Kondorosi">Éva Kondorosi</name><name sortKey="Kylarova, Salome" sort="Kylarova, Salome" uniqKey="Kylarova S" first="Salome" last="Kylarová">Salome Kylarová</name></country><country name="France"><region name="Île-de-France"><name sortKey="Mergaert, Peter" sort="Mergaert, Peter" uniqKey="Mergaert P" first="Peter" last="Mergaert">Peter Mergaert</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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